• Luminescent ATP Detection Assay Kit in NSCLC

  2026-08-22

  Use a firefly luciferase ATP assay to connect pyruvate carboxylase activity with energy status, ferroptosis susceptibility, and tumor progression in NSCLC models. The workflow combines rapid lysis, broad 1 nM–10 μM linearity, and downstream-compatible sample handling for cellular and tissue studies.

• Palmitic acid: Protocol Parameters and QC

  2026-08-22

  Palmitic acid (SKU N2456), also called hexadecanoic acid, provides a defined saturated long-chain fatty acid for lipid metabolism, signaling, and metabolic disorder research. It is intended for solvent-based preparation and prompt use, not aqueous dissolution or long-term storage as a solution.

• Acetylcholine Chloride in Gut-Brain Assays

  2026-08-21

  Acetylcholine Chloride provides a defined cholinergic comparator for testing how microbial signals influence vagal, intestinal, and neuronal function. This practical guide connects the Bacteroides fragilis antiseizure study with reproducible formulation, concentration-response, ex vivo, and troubleshooting workflows.

• GANT61: A GLI Inhibitor for Assay Design

  2026-08-20

  GANT61 is a GLI inhibitor for dissecting distal Hedgehog signaling in cancer models. This article presents an assay-centered framework for connecting GLI2 activity with tumor-cell phenotypes, WNT and prostaglandin signals, and immune suppression without overinterpreting pathway-level results.

• Ciclesonide: From Prodrug Activation to Assay Design

  2026-08-20

  Ciclesonide research depends on separating prodrug activation, glucocorticoid receptor binding, and downstream inflammatory outcomes. This article presents an assay-centered framework and clarifies what ERAD-hijacking research does—and does not—mean for respiratory models.

• AZD8055: Practical mTOR Inhibitor Workflow

  2026-08-19

  AZD8055 is a selective ATP-competitive mTOR inhibitor for dissecting mTORC1 and mTORC2 signaling in biochemical, cellular, and selected preclinical models. It is best suited to mechanistic research rather than clinical efficacy assessment, and its poor water and ethanol solubility requires disciplined DMSO-based handling.

• What AKT Inhibitor Pharmacology Reveals

  2026-08-19

  Kostaras and colleagues systematically compared ATP-competitive and allosteric AKT inhibitors using biochemical, cellular, structural, and phosphoproteomic approaches. Their findings show that inhibitor class, AKT isoform, mutation status, and non-catalytic signaling can strongly shape drug activity, offering a framework for interpreting context-specific responses and rational combinations.

• Azathramycin A: From Degradant to TB Assay Tool

  2026-08-18

  Azathramycin A is a macrolide antibiotic that can serve as both a mechanistic probe and an analytical control in tuberculosis research. This guide connects ribosome-focused assay design with compound identity, degradation, and interpretation decisions for more reproducible Mycobacterium tuberculosis studies.

• Homoharringtonine: From Ribosome to Assay Design

  2026-08-18

  Homoharringtonine is a cytotoxic alkaloid whose ribosome-directed activity connects leukemia research with SARS-CoV-2 antiviral research. This evidence-centered guide explains how to distinguish translational inhibition, cytotoxicity, and antiviral effects when designing robust assays.

• BFH772 (VEGFR2 inhibitor): Workflow Guide

  2026-08-17

  BFH772 is a selective small-molecule VEGFR2 inhibitor for experiments that require controlled modulation of VEGFR2-driven angiogenesis and tumor-model signaling. Its organic-solvent solubility and water insolubility make it unsuitable for workflows requiring aqueous formulation or broad-spectrum kinase inhibition without additional formulation and selectivity controls.

• IR-1061-Loaded Polystyrene Nanoparticles for Deep Imaging

  2026-08-17

  The reference study established a formulation strategy for highly emissive over-1000-nm nanoparticles by matching the polarity of IR-1061 with a tunable polystyrene-based matrix and optimizing the swelling–diffusion loading process. PEG modification further improved physiological dispersion and supported dynamic deep-tissue imaging in mice, offering practical design principles for near-infrared fluorescent dye formulations.

• Ciclesonide, ERAD, and Translational Precision

  2026-08-16

  Ciclesonide offers a useful model for studying site-selective glucocorticoid activation in respiratory tissues. Its conversion to the far more potent desisobutyryl-ciclesonide provides a mechanistic framework for asthma and allergic rhinitis research, while recent ERAD-engaging chimera work suggests how researchers can think more rigorously about intracellular routing, target accessibility, and translational assay design.

• Alternariol and Liver Fibrosis: LX-2 Evidence

  2026-08-14

  The reference study shows that Alternariol (AOH) and alternariol monomethyl ether can drive LX-2 hepatic stellate cells toward a contractile, myofibroblast-like state, linking emerging Alternaria toxins to liver-fibrosis biology. By combining lncRNA-mRNA omics with pathway-focused experiments, the authors identify NF-κB, ferroptosis, autophagy, and CotA-mediated detoxification as important directions for follow-up research.

• A23187, free acid: Calcium Ionophore Workflows

  2026-08-14

  A23187, free acid is a calcium ionophore for controlled intracellular Ca2+ elevation, mechanistic apoptosis studies, and stress-response assays. This practical guide links dose and time optimization to orthogonal readouts so researchers can distinguish calcium signaling, growth arrest, and cell death.

• Carbapenemase Gene Transmission in CREC

  2026-08-13

  This BMC Microbiology study characterizes carbapenemase-encoding genes in carbapenem-resistant Enterobacter cloacae collected across eight teaching hospitals in Guangdong, China. Its main contribution is linking gene location, antimicrobial resistance, conjugative transfer, mobile genetic elements, and strain relatedness to show how blaNDM-1-associated resistance may disseminate across clinical settings.

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