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Recently the toxicity of TBT was demonstrated
2022-03-14
Recently, the toxicity of TBT was demonstrated at the vascular level in animal models (Nath, 2008), and the results obtained so far suggest that TBT may be a potential risk factor for cardiovascular diseases. TBT is capable to alter the coronary vascular reactivity to estradiol (dos Santos et al., 2
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br Results br Discussion Our current study demonstrates that
2022-03-14
Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros
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br Hedgehog pathway The Hedgehog pathway
2022-03-14
Hedgehog pathway The Hedgehog pathway (Fig. 1) derives its name from Hh gene mutant Drosophila, which presents a spiked phenotype resembling the animal “hedgehog” [13]. The Hh proteins control embryonic development in vertebrates, where the signaling mechanisms mediated by the proteins are multip
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The rationale for developing HDACi as anticancer agents was
2022-03-14
The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and Volasertib arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of hematolog
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We have shown previously that activation of the
2022-03-14
We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates Silmitasertib cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-genomic TGFβ-induced c
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Efaproxiral Sodium Introduction Glycogen synthase kinase GSK
2022-03-12
Introduction Glycogen synthase kinase-3 (GSK-3) is an enzyme playing multiple roles in animal tissues and organs, and Efaproxiral Sodium is not an exception. Apart from involvement in regulation of apoptosis and survival GSK-3 influences neuronal morphology, synapse formation, memory reconsolidati
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br Introduction In the treatment of
2022-03-12
Introduction In the treatment of patients with AIDS and human immunodeficiency virus type 1 (HIV-1), anti-retroviral therapy (ART), which uses anti-HIV drugs such as protease inhibitors, integrase inhibitors and reverse transferase inhibitors, has made a major contribution. There are still some s
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br Conclusion br Author contributions br Competing interests
2022-03-12
Conclusion Author contributions Competing interests Acknowledgments Introduction Reproductive performance is a major factor affecting profitability of dairy farms. The use of GnRH and prostaglandin F2α (PGF2α) in a coordinated fashion allows cows to be inseminated as a result of the u
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Through the analysis of various synthetic
2022-03-12
Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic Guvacoline hydrobromide motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of
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br Materials and methods br Results
2022-03-12
Materials and methods Results Discussion In the CNS, GLP-1R is associated with G-protein signal transduction pathways, which can activate adenylyl cyclase and protein kinase A by cyclic adenosine monophosphate, and mediates neuronal activities implicated in various pathophysiological change
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Free d glutamate also has been found in various
2022-03-12
Free d-glutamate also has been found in various tissues of invertebrates and vertebrates including mammals (Han et al., 2011; Ariyoshi et al., 2017), fish (Kera et al., 2001) amphibians (Kera et al., 2001), birds (Kera et al., 2001), mollusks (Tarui et al., 2003; Patel et al., 2017) and arthropods (
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Nano SiO was a kind of versatile material
2022-03-12
Nano-SiO2 was a kind of versatile material for enzyme immobilization because of its excellent properties, including low cost, lack of toxicity, high stability, large specific surface area and high biocompatibility [10]. After the immobilization on nano-SiO2, the selectivity of enzymatic reactions wo
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With the advent of genome
2022-03-12
With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the
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Apoptosis a form of programmed cell death is a critical
2022-03-12
Apoptosis, a form of programmed cell death, is a critical component in maintaining homeostasis and growth in all tissues and plays a significant role in immunity and cytotoxicity [54,55]. Although GR are expressed in all immune cells, the physiological outcomes of GR activation are highly cell type-
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Work in the Ruiz i Altaba lab was
2022-03-12
Work in the Ruiz i Altaba lab was funded by grants from the Swiss National Science Foundation, the Ligue Suisse Contre le Cancer, the European FP7 Marie-Curie Initial Training Network HEALING, a James McDonnell Foundation 21st Century Science Initiative in Brain Cancer-Research Award and funds from
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