• br Materials and methods br

  2022-10-08

  

  Materials and methods Results Discussion ERK5 signaling and its regulation has gained focus in recent years specially in the subject of cardiovascular biology, where this kinase plays a key role in angiogenesis and maintenance of blood vessel integrity [18,20,34,35]. The signaling pathways

• It is well established that transcription factors are the

  2022-10-08

  

  It is well established that transcription factors are the major key players in regulating the transcriptional state of the targeted gene. 15 TFs were found in the present study, which were predicted to have the binding affinity with the EZH2 promoter region. Out of these, GCF, AP-2 and Sp1 were most

• According to the World Health Organization WHO classificatio

  2022-10-08

  

  According to the World Health Organization (WHO) classification, oligodendrogliomas or anaplastic oligodendrogliomas are primary neoplasms of the central nervous system, which are predominantly composed of cells morphologically resembling oligodendrocytes [23]. These tumors are often estimated to re

• JMJD C is another JmjC domain protein discovered as

  2022-10-08

  

  JMJD1C is another JmjC domain protein discovered as a putative oncogene in shRNA screens in MLL-AF9-, HOXA9-, and AML1-ETO-driven AML 40, 41, 42. Depletion of JMJD1C decreased the frequency of LICs by inducing their differentiation and impaired the growth and establishment of leukemia in serial tran

• CTX0294885 A complimentary approach with Per Luc cells expos

  2022-10-08

  

  A complimentary approach with Per2:Luc CTX0294885 exposed to hypoxia as well as with mBmal1:Luc circadian reporter cells in which we overexpressed variants of HIF-1α and HIF-2α revealed that hypoxia and HIFs can not only shorten the period but also decrease the amplitude of the clock (Figures 2 and

• br Acknowledgments The authors gratefully acknowledge the fi

  2022-10-05

  

  Acknowledgments The authors gratefully acknowledge the financial support of this study by STCU Project 6052 “Enzyme multibiosensor system for renal dysfunction diagnosis and hemodialysis control”. Furthermore, this study was supported by NASU in the frame of Scientific and Technical Program “Sens

• br Acknowledgments The authors gratefully acknowledge the fi

  2022-10-05

  

  Acknowledgments The authors gratefully acknowledge the financial support of this study by STCU Project 6052 “Enzyme multibiosensor system for renal dysfunction diagnosis and hemodialysis control”. Furthermore, this study was supported by NASU in the frame of Scientific and Technical Program “Sens

• Finally worth of mention are

  2022-10-04

  

  Finally, worth of mention are few papers that report on the discovery of HO-2 selective inhibitors. In 2013, starting from the screening of a 8-Azido-ATP library, the above-mentioned Canadian research group identified Clemizole (Table 6) as a new hit compound for the development of the first series

• br Activation of soluble guanylate cyclase The molecular ste

  2022-10-04

  

  Activation of soluble guanylate cyclase The molecular steps involved in sGC activation have evolved significantly over the last several years. The key studies are outlined below, but here we provide an overall summary. The activation mechanism of sGC was initially proposed to be relatively simple

• The development of immobilization techniques for

  2022-10-04

  

  The development of immobilization techniques for β-glucosidase offers a potential way to enable its reuse several times [13]. The aim of immobilization is to trap the enzyme within or on the surface of an insoluble material with retention of its catalytic activity [14]. The immobilization strategy a

• One may carefully evaluate the concept

  2022-10-03

  

  One may carefully evaluate the concept ‘pancreas derived GLP-1′ as this may dependent on the specificity of the SW033291 sale used in immunohistochemistry or radiommunoassays. If either a side-viewing antibody or a C-terminal wrapping antibody raised against GLP-1 is applied one may also identify N

• ETV plays an important role in

  2022-10-03

  

  ETV5 plays an important role in tumorigenesis and metastasis. For example, chromosomal rearrangement of ETV5 which results in increased ETV5 level is believed as a common event driving human prostate cancer (Helgeson et al., 2008; Huang and Waknitz, 2009). Ghrelin/acyl-ghrelin also plays an importan

• microRNAs miRNAs of approximately nucleotides play vital

  2022-10-02

  

  microRNAs (miRNAs) of approximately 22 nucleotides play vital roles in cancer development and progression by regulating translational repression or decay of target messenger RNAs (mRNAs) through their binding to the 3′-untranslated regions (3′-UTRs) of target mRNAs with imprecise or precise compleme

• Results of studies on fish FBPase are

  2022-10-02

  

  Results of studies on fish FBPase are somewhat confusing: although fishes skeletal muscles possess relatively high FBPase activity (Knox et al., 1980, Lushchak et al., 2001) and the isozyme present therein has kinetic properties typical to all vertebrates muscle FBPases (Rosenmann et al., 1977), inv

• GSTP has an antiapoptotic activity that is

  2022-10-01

  

  GSTP1 has an antiapoptotic activity that is mediated by the inhibitory interaction with JNK1. Our data suggest that GSTP1 treatment is associated with a significant down-regulation of caspase expression. This might explain the reduction in infarct-related cardiomyocyte death and saving the cardiomyo

14120 records 340/942 page Previous Next First page 上5页 336337338339340 下5页 Last page